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Image Search Results
Journal:
Article Title: Epidermal Growth Factor Facilitates Epinephrine Inhibition of P2X 7 -Receptor-Mediated Pore Formation and Apoptosis: A Novel Signaling Network
doi: 10.1210/en.2004-1026
Figure Lengend Snippet: Effects of day in culture and of treatments with EGF and epinephrine on the expression of the P2X 7 receptor
Article Snippet: Expression of the P2X 7 receptor protein was analyzed using the
Techniques: Expressing
Journal: Purinergic Signalling
Article Title: P2 X 7 receptor is a critical regulator of extracellular ATP-induced profibrotic genes expression in rat kidney: implication of transforming growth factor-β/Smad signaling pathway
doi: 10.1007/s11302-023-09977-4
Figure Lengend Snippet: Graphical abstract of the modulatory effect of ATP on the expression of the pro-fibrotic genes CTGF and TIMP-1 in rat kidney Binding of ATP to P2 X 7R triggers a rapid activation of latent TGF-β which in turn activates TGF-β receptors resulting in Smad phosphorylation. Then, phosphorylated Smads (p-Smad2/3) form a complex with smad-4 which moves into the nucleus and stimulate the expression of the profibrotic genes CTGF and TIMP-1. Adenosine 5′-triphosphate (ATP); The purinergic P2 X 7 receptor (P2 X 7R); A specific antagonist of P2 X 7 receptor (A 438,079); Connective tissue growth factor (CTGF); Tissue inhibitors of matrix metalloproteinases-1 (TIMP-1); Transforming growth factor-β (TGF-β); Transforming growth factor-β receptor I (TGF-βRI); Transforming growth factor-β receptor II (TGF-βRII).
Article Snippet: The
Techniques: Expressing, Binding Assay, Activation Assay